Olig3^{tm2(cre/ERT2)Cbm}
Targeted Allele Detail

Summary

• Symbol: Olig3^{tm2(cre/ERT2)Cbm}
• Name: oligodendrocyte transcription factor 3; targeted mutation 2, Carmen Birchmeier
• MGI ID: MGI:3833733
• Synonyms: Olig3^CreERT2
• Gene: Olig3 Location: Chr10:19232287-19234352 bp, + strand Genetic Position: Chr10, 8.33 cM
• Alliance: Olig3^{tm2(cre/ERT2)Cbm} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:143526
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutations: Insertion, Intragenic deletion
• Olig3^{tm2(cre/ERT2)Cbm} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Olig3 (MGI:2149955)

• Mutation details: A cre/ERT2 along with an Frt flanked neomycin selection cassette, replaces Olig3 coding sequence and was fused in frame with the ATG codon of Olig3. Mutant mice were later crossed with Gt(ROSA)26Sor^tm1(FLP1)Dym mice to excise the neomycin selection cassette. This is a null allele. (J:143526)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Olig3 (mouse) Summary of all recombinase alleles driven by Olig3. Alliance mouse Olig3 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Olig3 Mutation: 9 strains or lines available

References

• Original: J:143526 Storm R, et al., The bHLH transcription factor Olig3 marks the dorsal neuroepithelium of the hindbrain and is essential for the development of brainstem nuclei. Development. 2009 Jan;136(2):295-305
• All: 7 reference(s)