Supv3l1^tm2.1Jkl
Targeted Allele Detail

Summary

• Symbol: Supv3l1^tm2.1Jkl
• Name: suppressor of var1, 3-like 1 (S. cerevisiae); targeted mutation 2.1, Jan Klysik
• MGI ID: MGI:3833741
• Synonyms: Supv3L1^tm3Jkl
• Gene: Supv3l1 Location: Chr10:62264988-62285517 bp, - strand Genetic Position: Chr10, 32.4 cM
• Alliance: Supv3l1^tm2.1Jkl page

Thymic atrophy in Supv3l1^tm2.1Jkl/Supv3l1^tm2.2Jkl Tg(CAG-cre/Esr1*)5Amc/0 mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:144991
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Germ line, flp mediated recombination was used to remove the neo cassette leaving exon 14 floxed. (J:144991)

Targeting the Supv3l1 allele to generate the Supv3l1^tm2Jkl, Supv3l1^tm2.1Jkl, Supv3l1^tm2.2Jkl, and Supv3l1^tm2.3Jkl alleles

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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hm1	Supv3l1^tm2.1Jkl/Supv3l1^tm2.1Jkl	involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6
cn2	Supv3l1^tm2.1Jkl/Supv3l1^tm2.2Jkl Tg(KRT14-cre/ERT)20Efu/0	involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * CD-1 * FVB/N
cn3	Supv3l1^tm2.1Jkl/Supv3l1^tm2.2Jkl Tg(CAG-cre/Esr1*)5Amc/0	involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * FVB/N

Phenotypes:

Affected Systems	hm1	cn2	cn3
show or hide all annotated terms
adipose tissue		N	√
adipose tissue phenotype		N
decreased subcutaneous adipose tissue amount			√
behavior/neurological			√
abnormal locomotor behavior			√
cardiovascular system		√	√
dilated vasculature		√	√
cellular			√
increased macrophage derived foam cell number			√
digestive/alimentary system			√
abnormal duodenum morphology			√
endocrine/exocrine glands			√
thymus atrophy			√
thymus hypoplasia			√
decreased sebaceous gland number			√
growth/size/body			√
decreased body weight			√
cachexia			√
hematopoietic system			√
increased macrophage derived foam cell number			√
thymus atrophy			√
thymus hypoplasia			√
abnormal T cell differentiation			√
decreased double-negative T cell number			√
decreased double-positive T cell number			√
decreased CD4-positive, alpha-beta T cell number			√
decreased CD8-positive, alpha-beta T cell number			√
immune system			√
increased macrophage derived foam cell number			√
thymus atrophy			√
thymus hypoplasia			√
abnormal T cell differentiation			√
decreased double-negative T cell number			√
decreased double-positive T cell number			√
decreased CD4-positive, alpha-beta T cell number			√
decreased CD8-positive, alpha-beta T cell number			√
lung inflammation			√
integument		√	√
integument phenotype		N	N
decreased subcutaneous adipose tissue amount			√
decreased sebaceous gland number			√
abnormal skin morphology			√
abnormal dermal layer morphology		√	√
hyperkeratosis		√	√
parakeratosis		√	√
abnormal epidermis stratum granulosum morphology			√
acanthosis		√	√
thick epidermis		√	√
reddish skin		√	√
scaly skin		√	√
mortality/aging			√
premature death			√
muscle			√
decreased skeletal muscle mass			√
dystrophic muscle			√
respiratory system			√
lung inflammation			√
abnormal lung interstitium morphology			√
skeleton			√
kyphosis			√
normal phenotype	√
no abnormal phenotype detected	√

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

15 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Supv3l1 Mutation: 42 strains or lines available

References

• Original: J:144991 Paul E, et al., Disruption of Supv3L1 damages the skin and causes sarcopenia, loss of fat, and death. Mamm Genome. 2009 Feb;20(2):92-108
• All: 1 reference(s)