Supv3l1^tm2.1Jkl
Targeted Allele Detail

Summary

• Symbol: Supv3l1^tm2.1Jkl
• Name: suppressor of var1, 3-like 1 (S. cerevisiae); targeted mutation 2.1, Jan Klysik
• MGI ID: MGI:3833741
• Synonyms: Supv3L1^tm3Jkl
• Gene: Supv3l1 Location: Chr10:62264988-62285517 bp, - strand Genetic Position: Chr10, 32.4 cM
• Alliance: Supv3l1^tm2.1Jkl page

Thymic atrophy in Supv3l1^tm2.1Jkl/Supv3l1^tm2.2Jkl Tg(CAG-cre/Esr1*)5Amc/0 mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:144991
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Germ line, flp mediated recombination was used to remove the neo cassette leaving exon 14 floxed. (J:144991)

Targeting the Supv3l1 allele to generate the Supv3l1^tm2Jkl, Supv3l1^tm2.1Jkl, Supv3l1^tm2.2Jkl, and Supv3l1^tm2.3Jkl alleles

Expression

In Structures Affected by this Mutation:

15 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Supv3l1 Mutation: 42 strains or lines available

References

• Original: J:144991 Paul E, et al., Disruption of Supv3L1 damages the skin and causes sarcopenia, loss of fat, and death. Mamm Genome. 2009 Feb;20(2):92-108
• All: 1 reference(s)