Dab1^tm6Cpr
Targeted Allele Detail

Summary

• Symbol: Dab1^tm6Cpr
• Name: disabled 1; targeted mutation 6, Jonathan A Cooper
• MGI ID: MGI:3833830
• Synonyms: Dab1^cd
• Gene: Dab1 Location: Chr4:103476556-104602041 bp, + strand Genetic Position: Chr4, 47.79 cM
• Alliance: Dab1^tm6Cpr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:145031
• Parent Cell Line: AK7 (ES Cell)
• Strain of Origin: 129S4/SvJaeSor

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Intragenic deletion
• Mutation details: the exon encoding amino acids 23 through 69 was replaced with a construct containing a splice acceptor and a modified partial cDNA encoding the p80 splice form. The cDNA was modified to encode phenylalanines in place of 2 tyrosines residues (220, 232) that are phosphorylation sites. A floxed neomycin selection cassette was excised by transient cre expression. (J:145031)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dab1 Mutation: 79 strains or lines available

References

• Original: J:145031 Feng L, et al., Dual functions of Dab1 during brain development. Mol Cell Biol. 2009 Jan;29(2):324-32
• All: 1 reference(s)