Itprid2^tm1Sawa
Targeted Allele Detail

Summary

• Symbol: Itprid2^tm1Sawa
• Name: ITPR interacting domain containing 2; targeted mutation 1, Senji Shirasawa
• MGI ID: MGI:3833897
• Synonyms: KRAP^-
• Gene: Itprid2 Location: Chr2:79465696-79503310 bp, + strand Genetic Position: Chr2, 47.58 cM, cytoband D
• Alliance: Itprid2^tm1Sawa page

Resistance to fatty liver formation in Itprid2^tm1Sawa/Itprid2^tm1Sawa mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:144968
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: Exons 11 - 16, encompassing 55% of the coding region of the gene, were replaced with a neo cassette via homologous recombination. Western blot analysis confirmed the absence of protein expression in livers from homozygous mice. (J:144968)

Generation of the Itprid2^tm1Sawa allele

Expression

In Mice Carrying this Mutation:	2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Itprid2 Mutation: 51 strains or lines available

References

• Original: J:144968 Fujimoto T, et al., Altered energy homeostasis and resistance to diet-induced obesity in KRAP-deficient mice. PLoS One. 2009;4(1):e4240
• All: 2 reference(s)