Sgpl1^{tm1(SGPL1)Lex}
Targeted Allele Detail

Summary

• Symbol: Sgpl1^{tm1(SGPL1)Lex}
• Name: sphingosine phosphate lyase 1; targeted mutation 1, Lexicon Genetics
• MGI ID: MGI:3833933
• Synonyms: S1PL^H
• Gene: Sgpl1 Location: Chr10:60934421-60983463 bp, - strand Genetic Position: Chr10, 32.14 cM
• Alliance: Sgpl1^{tm1(SGPL1)Lex} page

Thymus abnormalities in Sgpl1^{Gt(OST58278)Lex}/Sgpl1^{Gt(OST58278)Lex}, Sgpl1^{tm1(SGPL1)Lex}/Sgpl1^{tm1(SGPL1)Lex} and Sgpl1^{tm1(SGPL1)Lex}/Sgpl1^{Gt(OST58278)Lex} mice

Show the 6 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:145159
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S5/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Targeted (Humanized sequence, Inserted expressed sequence)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2 was replaced with a cDNA for the human gene and a floxed neo cassette. Germ line, cre-mediated recombination was used to remove the neo cassette. Enzymatic activity is decreased to 17% of wild-type. (J:145159)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sgpl1 Mutation: 33 strains or lines available

References

• Original: J:145159 Vogel P, et al., Incomplete inhibition of sphingosine 1-phosphate lyase modulates immune system function yet prevents early lethality and non-lymphoid lesions. PLoS One. 2009;4(1):e4112
• All: 1 reference(s)