Gng7^{tm2(cre/PGR)Mmsh}
Targeted Allele Detail

Summary

• Symbol: Gng7^{tm2(cre/PGR)Mmsh}
• Name: guanine nucleotide binding protein (G protein), gamma 7; targeted mutation 2, Masayoshi Mishina
• MGI ID: MGI:3833956
• Synonyms: Gng7^mCrePR
• Gene: Gng7 Location: Chr10:80784463-80850742 bp, - strand Genetic Position: Chr10, 39.72 cM
• Alliance: Gng7^{tm2(cre/PGR)Mmsh} page

Ablation of medium-spiny projection neurons in the striatum of Gng7^{tm2(cre/PGR)Mmsh}/Gng7⁺ Eno2^tm1(DTA)Hsak/Eno2⁺ mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:145152
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Inducible, Recombinase)
• Inducer: mifepristone
• Mutation: Insertion
• Gng7^{tm2(cre/PGR)Mmsh} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Gng7 (MGI:95787)

• Mutation details: An inducible cre cassette consisting of mammalian optimized cre fused to the human progesterone receptor followed by a neo selection cassette in the inverse orientation were inserted into the translation initiation site via homologous recombination. Following RU-496 treatment no Cre activity was detected in brain slices. (J:145152)

Generation of the Gng7^tm1(cre)Mmsh and Gng7^{tm2(cre/PGR)Mmsh} alleles

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Gng7 (mouse) Summary of all recombinase alleles driven by Gng7. Alliance mouse Gng7 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gng7 Mutation: 75 strains or lines available

References

• Original: J:145152 Kishioka A, et al., A novel form of memory for auditory fear conditioning at a low-intensity unconditioned stimulus. PLoS One. 2009;4(1):e4157
• All: 3 reference(s)