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Tg(Myh6-Pln)11Egk
Transgene Detail
Summary
Symbol: Tg(Myh6-Pln)11Egk
Name: transgene insertion 11, Evangelia G Kranias
MGI ID: MGI:3833963
Synonyms: S16A mutant PLB, S16A PLB, Ser16-->Ala mutant PLB, Tg(Pln)11Egk
Transgene: Tg(Myh6-Pln)11Egk  Location: unknown  
Alliance: Tg(Myh6-Pln)11Egk page
Transgene
origin
Strain of Origin:  Not Specified
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Myh6-Pln)11Egk expresses 1 gene
 
Mutation detailsThe transgene contains a mouse cardiac phospholamban cDNA with a point mutation (TCC->GCC) that encodes alanine instead of serine at amino acid position 16 of the protein (S16A), followed by an SV40 polyadenylation signal, under control of the cardiac specific alpha myosin heavy chain (myosin, heavy polypeptide 6, cardiac muscle, alpha) promoter. The replaced serine normally is phosphorylated in response to stimulation of cardiac muscle beta adrenergic receptors. Northern blot analysis revealed cardiac expression of the 1.0 kb transcript from the transgene, and quantitative immunoblot analysis demonstrated expression of phospholamban protein in the hearts of transgenic mice homozygous for a null phospholamban allele. (J:119619, J:135899)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:119619 Luo W, et al., Transgenic approaches to define the functional role of dual site phospholamban phosphorylation. J Biol Chem. 1998 Feb 20;273(8):4734-9
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory