Egfr^tm1.1Dwt
Targeted Allele Detail

Summary

• Symbol: Egfr^tm1.1Dwt
• Name: epidermal growth factor receptor; targeted mutation 1.1, David W Threadgill
• MGI ID: MGI:3834077
• Synonyms: Egfr^delta
• Gene: Egfr Location: Chr11:16702203-16868158 bp, + strand Genetic Position: Chr11, 9.41 cM, cytoband A1-A4
• Alliance: Egfr^tm1.1Dwt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:145069
• Parent Cell Line: TL1/TL-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Germ line, cre mediated recombination was used to remove exon 3. The absence of protein expression was confirmed by western blot analysis on dorsal root ganglion extracts. (J:145151)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Egfr Mutation: 87 strains or lines available

References

• Original: J:145069 Maklad A, et al., The EGFR is required for proper innervation to the skin. J Invest Dermatol. 2009 Mar;129(3):690-8
• All: 5 reference(s)