Rab27b^tm1Tiz
Targeted Allele Detail

Summary

• Symbol: Rab27b^tm1Tiz
• Name: RAB27B, member RAS oncogene family; targeted mutation 1, Tetsuro Izumi
• MGI ID: MGI:3834149
• Gene: Rab27b Location: Chr18:70112202-70274676 bp, - strand Genetic Position: Chr18, 43.89 cM
• Alliance: Rab27b^tm1Tiz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:145238
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: Exon 2 was replaced with a lacZ and floxed neo cassette. The absence of protein expression was confirmed by western blot analysis on brain, pituitary, and spleen extracts. (J:145238)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Rab27b Mutation: 28 strains or lines available

References

• Original: J:145238 Gomi H, et al., Rab27b is expressed in a wide range of exocytic cells and involved in the delivery of secretory granules near the plasma membrane. Mol Biol Cell. 2007 Nov;18(11):4377-86
• All: 1 reference(s)