Eaf2^tm1Zhow
Targeted Allele Detail

Summary

• Symbol: Eaf2^tm1Zhow
• Name: ELL associated factor 2; targeted mutation 1, Zhou Wang
• MGI ID: MGI:3834174
• Synonyms: U19^-
• Gene: Eaf2 Location: Chr16:36613246-36695275 bp, - strand Genetic Position: Chr16, 26.05 cM
• Alliance: Eaf2^tm1Zhow page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:145228
• Parent Cell Line: HM-1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd-Hprt1^b-m3

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2 was replaced with a neo cassette. The absence of protein expression was confirmed by western blot analysis on mouse embryonic fibroblasts. (J:145228)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	5 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Eaf2^tm1Zhow

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Eaf2 Mutation: 19 strains or lines available

References

• Original: J:145228 Xiao W, et al., U19/Eaf2 knockout causes lung adenocarcinoma, B-cell lymphoma, hepatocellular carcinoma and prostatic intraepithelial neoplasia. Oncogene. 2008 Mar 6;27(11):1536-44
• All: 8 reference(s)