Mbl1^tm1Rala
Targeted Allele Detail

Summary

• Symbol: Mbl1^tm1Rala
• Name: mannose-binding lectin (protein A) 1; targeted mutation 1, Rachel A Lawrence
• MGI ID: MGI:3834180
• Synonyms: MBL-A^-
• Gene: Mbl1 Location: Chr14:40873415-40881558 bp, + strand Genetic Position: Chr14, 22.36 cM
• Alliance: Mbl1^tm1Rala page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:145279
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 2 kb region containing exons 2 and 3 which encode the translationb start site and the collagenous domain was replaced with a neomycin resistance cassette inserted in reverse orientation. Northern blot and Western blot analyses confirmed the absence of mRNA and of protein product. (J:145279)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mbl1 Mutation: 23 strains or lines available

References

• Original: J:145279 Carter T, et al., Mannose-binding lectin A-deficient mice have abrogated antigen-specific IgM responses and increased susceptibility to a nematode infection. J Immunol. 2007 Apr 15;178(8):5116-23
• All: 1 reference(s)