Lyz2^{tm1(HBEGF)Mtka}
Targeted Allele Detail

Summary

• Symbol: Lyz2^{tm1(HBEGF)Mtka}
• Name: lysozyme 2; targeted mutation 1, Masato Tanaka
• MGI ID: MGI:3834185
• Synonyms: LysM-DTR, Lyz2^tm1(DTR)Mtka
• Gene: Lyz2 Location: Chr10:117113446-117118177 bp, - strand Genetic Position: Chr10, 65.34 cM
• Alliance: Lyz2^{tm1(HBEGF)Mtka} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:145285
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutations: Insertion, Intragenic deletion
• Lyz2^{tm1(HBEGF)Mtka} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  HBEGF (1839)

  Hbegf

  (MGI:96070)

• Mutation details: Exon 1 was replaced with a cDNA for human diphtheria toxin receptor, heparin-binding epidermal growth factor-like growth factor (HB-EGF), and a floxed neo cassette. (J:145285)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Lyz2 Mutation: 40 strains or lines available

References

• Original: J:145285 Miyake Y, et al., Protective role of macrophages in noninflammatory lung injury caused by selective ablation of alveolar epithelial type II Cells. J Immunol. 2007 Apr 15;178(8):5001-9
• All: 3 reference(s)