Tg(tetO-PIK3CA*H1047R)13Lca
Transgene Detail

Summary

• Symbol: Tg(tetO-PIK3CA*H1047R)13Lca
• Name: transgene insertion 13, Lewis C Cantley
• MGI ID: MGI:3834439
• Synonyms: p110-alpha H1047R
• Transgene: Tg(tetO-PIK3CA*H1047R)13Lca Location: unknown
• Alliance: Tg(tetO-PIK3CA*H1047R)13Lca page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inducible, Inserted expressed sequence)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Tg(tetO-PIK3CA*H1047R)13Lca expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  PIK3CA (5290)

  Pik3ca

  (MGI:1206581)

• Mutation details: The tetracyclin operator was used to drive expression of the human cDNA with a point mutation that results in the amino acid substitution of arginine for histidine at position 1047 (H1047R). Three lines were generated (13, 121 and 3011). Line 13 carries around 20 copies of the transgene compared to around 60 in line 121. (J:142254)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:142254 Engelman JA, et al., Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers. Nat Med. 2008 Dec;14(12):1351-6
• All: 1 reference(s)