Slitrk1^tm1Jaru
Targeted Allele Detail

Summary

• Symbol: Slitrk1^tm1Jaru
• Name: SLIT and NTRK-like family, member 1; targeted mutation 1, Jun Aruga
• MGI ID: MGI:3834477
• Gene: Slitrk1 Location: Chr14:109147420-109151671 bp, - strand Genetic Position: Chr14, 56.78 cM, cytoband E3
• Alliance: Slitrk1^tm1Jaru page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:145441
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was designed to delete 2.5 kb of the exon containing entire open-reading frame. A floxed neo replaced the sequence and was subsequently excised by crossing with mice expressing Cre in the germ line. Western blot of mutant brain samples showed no bands corresponding to Slitrk1 protein. (J:145441)

Disease models

Expression

In Mice Carrying this Mutation:	5 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Slitrk1 Mutation: 35 strains or lines available

References

• Original: J:145441 Katayama K, et al., Slitrk1-deficient mice display elevated anxiety-like behavior and noradrenergic abnormalities. Mol Psychiatry. 2010 Feb;15(2):177-84
• All: 2 reference(s)