Tg(ATN1*)Drm21Stsu
Transgene Detail

Summary

• Symbol: Tg(ATN1*)Drm21Stsu
• Name: transgene insertion Drm21, Shoji Tsuji
• MGI ID: MGI:3834571
• Synonyms: Drm21
• Transgene: Tg(ATN1*)Drm21Stsu Location: unknown
• Alliance: Tg(ATN1*)Drm21Stsu page

Transgene origin

• Germline Transmission: Earliest citation of germline transmission: J:52439
• Parent Cell Line: CCE/EK.CCE (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(ATN1*)Drm21Stsu expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  ATN1 (1822)

  Atn1	(MGI:104725)

• Mutation details: The transgene was engineered from BAC DRPLA18E that contains the human gene for ATN1 from a patient with dentatorubral-pallidoluysian atrophy (DRPLA) with a 76 CAG trinucleotide repeat within the gene. Three lines were created (lines Drm12, Drm21, and Drm22) with 78, 76 and 77 CAG repeats, respectively. (J:52439)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:52439 Sato T, et al., Transgenic mice harboring a full-length human mutant DRPLA gene exhibit age-dependent intergenerational and somatic instabilities of CAG repeats comparable with those in DRPLA patients. Hum Mol Genet. 1999 Jan;8(1):99-106
• All: 2 reference(s)