Gt(ROSA)26Sor^{tm1(Dkk1)Flng}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1(Dkk1)Flng}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Fanxin Long
• MGI ID: MGI:3834604
• Synonyms: R26-Dkk1
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1(Dkk1)Flng} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:145305
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Conditional ready, Inserted expressed sequence)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm1(Dkk1)Flng} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Dkk1 (MGI:1329040)

• Mutation details: A full-length cDNA preceded by a floxed-STOP cassette and followed by IRES2-GFP was inserted into the locus. Expression of the cDNA is only achieved following cre mediated recombination. (J:145305)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 992 strains or lines available

References

• Original: J:145305 Wu X, et al., Rac1 activation controls nuclear localization of beta-catenin during canonical Wnt signaling. Cell. 2008 Apr 18;133(2):340-53
• All: 1 reference(s)