Crtam^tm1Achn
Targeted Allele Detail

Summary

• Symbol: Crtam^tm1Achn
• Name: cytotoxic and regulatory T cell molecule; targeted mutation 1, Andrew C Chan
• MGI ID: MGI:3834613
• Gene: Crtam Location: Chr9:40880987-40915922 bp, - strand Genetic Position: Chr9, 21.79 cM
• Alliance: Crtam^tm1Achn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:145314
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A LacZ/neo cassette replaced exon 1 of the gene locus, deleting the ATG start site. No protein was detected in CD4⁺ or CD8⁺ T cells by immunoblot or flow cytometry assays. (J:145314)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Crtam Mutation: 21 strains or lines available

References

• Original: J:145314 Yeh JH, et al., Regulation of a late phase of T cell polarity and effector functions by Crtam. Cell. 2008 Mar 7;132(5):846-59
• All: 1 reference(s)