Kdm1a^tm1.2Tche
Targeted Allele Detail

Summary

• Symbol: Kdm1a^tm1.2Tche
• Name: lysine (K)-specific demethylase 1A; targeted mutation 1.2, Taiping Chen
• MGI ID: MGI:3834630
• Synonyms: Aof2^1lox
• Gene: Kdm1a Location: Chr4:136277851-136330034 bp, - strand Genetic Position: Chr4, 68.8 cM
• Alliance: Kdm1a^tm1.2Tche page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:144527
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Germ line, cre mediated recombination was used to remove exons 10 through 13 leading to a frame shift. The absence of protein expression was confirmed by western blot analysis on embryonic stem cells. (J:144527)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kdm1a Mutation: 39 strains or lines available

References

• Original: J:144527 Wang J, et al., The lysine demethylase LSD1 (KDM1) is required for maintenance of global DNA methylation. Nat Genet. 2009 Jan;41(1):125-9
• All: 2 reference(s)