Tg(tetO-BRAF*V600E)29Lc
Transgene Detail

Summary

• Symbol: Tg(tetO-BRAF*V600E)29Lc
• Name: transgene insertion 29, Lynda Chin
• MGI ID: MGI:3834721
• Synonyms: Tet-BRAF*
• Transgene: Tg(tetO-BRAF*V600E)29Lc Location: unknown
• Alliance: Tg(tetO-BRAF*V600E)29Lc page

Transgene origin

• Strain of Origin: Not Applicable

Transgene description

• Transgene Type: Transgenic (Constitutively active, Humanized sequence, Inducible, Inserted expressed sequence)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Tg(tetO-BRAF*V600E)29Lc expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  BRAF (673)

  Braf	(MGI:88190)

• Mutation details: The tetracycline operon was used to drive inducible expression of a human cDNA with nucleotide substitutions that result in the amino acid substitution of glutamic acid for valine at position 600 (V600E). This mutation creates a constitutively active form. Two lines were created (lines 29 and 13). Line 29 was selected as the representative line. (J:144358)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:144358 Jeong JH, et al., BRAF activation initiates but does not maintain invasive prostate adenocarcinoma. PLoS One. 2008;3(12):e3949
• All: 7 reference(s)