Socs3^tm1Robb
Targeted Allele Detail

Summary

• Symbol: Socs3^tm1Robb
• Name: suppressor of cytokine signaling 3; targeted mutation 1, Lorraine Robb
• MGI ID: MGI:3835162
• Synonyms: SOCS3^deltaSB
• Gene: Socs3 Location: Chr11:117856905-117860192 bp, - strand Genetic Position: Chr11, 82.96 cM, cytoband E2
• Alliance: Socs3^tm1Robb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:145513
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Hypomorph)
• Mutation: Intragenic deletion
• Mutation details: A 120 bp deletion of nucleotides 573-692 of the gene transcript was created in exon 2. This removes the 40 c-terminal amino acids. A floxed PGK-neomycin cassette was intruduced further downstream. The neomycin cassette was later removed by mating to transgenic Tg(CMV-cre)1Cgn mice. Immunological examination of protein extracts from liver confirmed that a truncated protein was expressed. (J:145513)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Socs3 Mutation: 21 strains or lines available

References

• Original: J:145513 Boyle K, et al., The SOCS box of suppressor of cytokine signaling-3 contributes to the control of G-CSF responsiveness in vivo. Blood. 2007 Sep 1;110(5):1466-74
• All: 1 reference(s)