Baiap2^Gt(XG757)Byg
Gene trapped Allele Detail

Summary

• Symbol: Baiap2^Gt(XG757)Byg
• Name: brain-specific angiogenesis inhibitor 1-associated protein 2; gene trap XG757, BayGenomics
• MGI ID: MGI:3835373
• Synonyms: IRSp53^-
• Gene: Baiap2 Location: Chr11:119833762-119897608 bp, + strand Genetic Position: Chr11, 83.96 cM, cytoband E2
• Alliance: Baiap2^Gt(XG757)Byg page

Mutation origin

• Mutant Cell Line: XG757
• Germline Transmission: Earliest citation of germline transmission: J:144939
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector Vector: pGT1Lxf Vector Type: gene trap
• Mutation details: A gene trap vector containing the En2 splice acceptor upstream of the beta-geo (lacZ-neomycin) gene and a polyadenylation signal was inserted into the intron between exons 3 and 4 of the gene. Absence of protein expression was confirmed in homozyous mice total brain homogenate by Western blot. (J:144939)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  XG757	CC200107 ; (MGI Seq Detail)	5' RACE	Chr11:119833915-119851067 bp (+)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  7 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Expression

In Mice Carrying this Mutation:	138 assay results
In Structures Affected by this Mutation:	19 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Baiap2 Mutation: 30 strains or lines available

Notes

All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.

References

• Original: J:144939 Kim MH, et al., Enhanced NMDA receptor-mediated synaptic transmission, enhanced long-term potentiation, and impaired learning and memory in mice lacking IRSp53. J Neurosci. 2009 Feb 4;29(5):1586-95
• All: 10 reference(s)