Tg(DBH-PTPN11)14Bmas
Transgene Detail

Summary

• Symbol: Tg(DBH-PTPN11)14Bmas
• Name: transgene insertion 14, Brian A Masters
• MGI ID: MGI:3835390
• Synonyms: OX14, TgN(DBH-SHP2)Bmas14, wtSHP-2
• Transgene: Tg(DBH-PTPN11)14Bmas Location: unknown
• Alliance: Tg(DBH-PTPN11)14Bmas page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(DBH-PTPN11)14Bmas expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  chicken	PTPN11 (395815)

• Mutation details: This transgene contains a 1.9 kb cDNA encoding chicken wild-type protein tyrosine phosphatase, non-receptor type 11 (also known as SHP-2) expressed under control of a 5.8 kb human dopamine beta-hydroxylase (dopamine beta-monooxygenase) promoter. The promoter is followed by the first intron of the rat insulin II gene. The cDNA is joined at its 3' end to a 799 bp fragment of the human growth hormone gene that contains 66 bp of coding sequence and the 633 bp 3' untranslated region (UTR), including the polyadenylation signal. Immunoblot analysis reveals that superior cervical ganglia of transgenic mice contain 2-2.5 fold the level of DBH as do those of non-transgenic animals. (J:80747, J:94077)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

This is one of three lines that expressed wild-type PTPN11: lines 2, 9 and 14. The phenotype is reported to be consistent among them. (J:80747)

References

• Original: J:80747 Chen B, et al., SHP-2 Mediates Target-Regulated Axonal Termination and NGF-Dependent Neurite Growth in Sympathetic Neurons. Dev Biol. 2002 Dec 15;252(2):170-87
• All: 2 reference(s)