Gtf2ird1^tm1Lro
Targeted Allele Detail

Summary

• Symbol: Gtf2ird1^tm1Lro
• Name: general transcription factor II I repeat domain-containing 1; targeted mutation 1, L R Osborne
• MGI ID: MGI:3835413
• Synonyms: Gtf2ird1^-
• Gene: Gtf2ird1 Location: Chr5:134386510-134485570 bp, - strand Genetic Position: Chr5, 74.55 cM
• Alliance: Gtf2ird1^tm1Lro page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:145599
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Sequences for both the long and short arms of the targeting vector were derived from RPCI-21-510M19 (PAC clone). A floxed PGK-neomycin resistance cassette replaced exons 2, 3, 4, and part of exon 5. RT-PCR analysis indicated the absence of full length transcript in the brain. A much shorter, truncated downstream message was detected. (J:145599)

Expression

In Mice Carrying this Mutation:	2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gtf2ird1 Mutation: 359 strains or lines available

References

• Original: J:145599 Young EJ, et al., Reduced fear and aggression and altered serotonin metabolism in Gtf2ird1-targeted mice. Genes Brain Behav. 2008 Mar;7(2):224-34
• All: 4 reference(s)