Ptpn5^tm1Pjlo
Targeted Allele Detail

Summary

• Symbol: Ptpn5^tm1Pjlo
• Name: protein tyrosine phosphatase, non-receptor type 5; targeted mutation 1, Paul J Lombroso
• MGI ID: MGI:3835526
• Synonyms: STEP^-
• Gene: Ptpn5 Location: Chr7:46727543-46783432 bp, - strand Genetic Position: Chr7, 30.7 cM, cytoband B3-B5
• Alliance: Ptpn5^tm1Pjlo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:145584
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: 1284 bp of genomic sequence encoding the catalytic site was replaced with a neo cassette. The absence of protein expression was confirmed by western blot analysis on brain extracts. (J:145584)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ptpn5 Mutation: 29 strains or lines available

References

• Original: J:145584 Venkitaramani DV, et al., Knockout of STriatal enriched protein tyrosine phosphatase in mice results in increased ERK1/2 phosphorylation. Synapse. 2009 Jan;63(1):69-81
• All: 22 reference(s)