Kmt2e^tm1.1Hjf
Targeted Allele Detail

Summary

• Symbol: Kmt2e^tm1.1Hjf
• Name: lysine (K)-specific methyltransferase 2E; targeted mutation 1.1, H J Fehling
• MGI ID: MGI:3835538
• Gene: Kmt2e Location: Chr5:23639439-23709233 bp, + strand Genetic Position: Chr5, 10.33 cM, cytoband A3
• Alliance: Kmt2e^tm1.1Hjf page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:145579
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 3 and 4 were removed by germ line, cre mediated. The absence of protein expression was confirmed by western blot analysis on testis and thymus extracts. (J:145579)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Kmt2e Mutation: 105 strains or lines available

References

• Original: J:145579 Madan V, et al., Impaired function of primitive hematopoietic cells in mice lacking the Mixed-Lineage-Leukemia homolog MLL5. Blood. 2009 Feb 12;113(7):1444-54
• All: 3 reference(s)