Npas4^tm1Ooe
Targeted Allele Detail

Summary

• Symbol: Npas4^tm1Ooe
• Name: neuronal PAS domain protein 4; targeted mutation 1, Norihisa Ooe
• MGI ID: MGI:3835590
• Synonyms: NXF^-
• Gene: Npas4 Location: Chr19:5034383-5040344 bp, - strand Genetic Position: Chr19, 4.2 cM
• Alliance: Npas4^tm1Ooe page

Brain damage in Npas4^tm1Ooe/Npas4^tm1Ooe mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:145569
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: Exons 1, 2, and 3 were replaced with a neo cassette. The absence of transcript expression was confirmed by real-time PCR on brain tissues. (J:145569)

Generation of the Npas4^tm1Ooe allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Npas4 Mutation: 27 strains or lines available

References

• Original: J:145569 Ooe N, et al., Functional characterization of basic helix-loop-helix-PAS type transcription factor NXF in vivo: putative involvement in an 'on demand' neuroprotection system. J Biol Chem. 2009 Jan 9;284(2):1057-63
• All: 1 reference(s)