Kmt2e^tm1Apa
Targeted Allele Detail

Summary

• Symbol: Kmt2e^tm1Apa
• Name: lysine (K)-specific methyltransferase 2E; targeted mutation 1, Samuel A Aparicio
• MGI ID: MGI:3835772
• Synonyms: Mll5^tm1Apa
• Gene: Kmt2e Location: Chr5:23639439-23709233 bp, + strand Genetic Position: Chr5, 10.33 cM, cytoband A3
• Alliance: Kmt2e^tm1Apa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:145445
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An IRES-Beta-gal reporter cassette and a loxP-flanked neomycin cassette was knocked into exon 3 of the gene locus. Gene inactivation was confirmed by a lack of protein detected in immunoblot analysis of homozygote thymus and spleen. (J:145445)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kmt2e Mutation: 105 strains or lines available

References

• Original: J:145445 Heuser M, et al., Loss of MLL5 results in pleiotropic hematopoietic defects, reduced neutrophil immune function, and extreme sensitivity to DNA demethylation. Blood. 2009 Feb 12;113(7):1432-43
• All: 2 reference(s)