Rad18^tm1Stat
Targeted Allele Detail

Summary

• Symbol: Rad18^tm1Stat
• Name: RAD18 E3 ubiquitin protein ligase; targeted mutation 1, Satoshi Tateishi
• MGI ID: MGI:3835812
• Gene: Rad18 Location: Chr6:112596811-112673647 bp, - strand Genetic Position: Chr6, 52.42 cM, cytoband F
• Alliance: Rad18^tm1Stat page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:145534
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A floxed IRES-beta-geo cassette with a polyadenylation sequence was inserted into the exon encoding amino acids Thr-90 through Lys-201. Transient cre expression was used to remove the IRES-beta-geo cassette. The absence of protein expression was confirmed by western blot analysis on mouse embryonic fibroblasts. (J:81138, J:145534)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rad18 Mutation: 31 strains or lines available

References

• Original: J:145534 Sun J, et al., Rad18 is required for long-term maintenance of spermatogenesis in mouse testes. Mech Dev. 2009 Mar-Apr;126(3-4):173-83
• All: 5 reference(s)