Tg(Scgb1a1-IL6)9Flv
Transgene Detail

Summary

• Symbol: Tg(Scgb1a1-IL6)9Flv
• Name: transgene insertion 9, Richard A Flavell
• MGI ID: MGI:3835842
• Synonyms: IL-6 TG
• Transgene: Tg(Scgb1a1-IL6)9Flv Location: unknown
• Alliance: Tg(Scgb1a1-IL6)9Flv page

Transgene origin

• Strain of Origin: (CBA x C57BL/6)F2

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Scgb1a1-IL6)9Flv expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  IL6 (3569)

  Il6	(MGI:96559)

• Mutation details: The rat CC10 promoter drives expression of a human IL6 gene in airway epithelial cells. In addition to the representative line 9, lines 11 and 17 were also produced. (J:128762)

Disease models

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:128762 DiCosmo BF, et al., Airway epithelial cell expression of interleukin-6 in transgenic mice. Uncoupling of airway inflammation and bronchial hyperreactivity. J Clin Invest. 1994 Nov;94(5):2028-35
• All: 11 reference(s)