Vsx2^tm1(DTA)Kash
Targeted Allele Detail

Summary

• Symbol: Vsx2^tm1(DTA)Kash
• Name: visual system homeobox 2; targeted mutation 1, Kamal Sharma
• MGI ID: MGI:3835936
• Synonyms: chx10^LNL-DTA, Chx10-lnl-DTA
• Gene: Vsx2 Location: Chr12:84616602-84642231 bp, + strand Genetic Position: Chr12, 39.28 cM
• Alliance: Vsx2^tm1(DTA)Kash page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:145621
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, Inserted expressed sequence)
• Mutations: Insertion, Intragenic deletion
• Mutation details: 176 bases of exon 1 containing the translation initiation site were replaced with a floxed STOP cassette followed by a cDNA for the diphtheria toxin A. Removal of the floxed STOP cassette is necessary for expression of DTA. (J:145621)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Vsx2 Mutation: 23 strains or lines available

References

• Original: J:145621 Crone SA, et al., Genetic ablation of V2a ipsilateral interneurons disrupts left-right locomotor coordination in mammalian spinal cord. Neuron. 2008 Oct 9;60(1):70-83
• All: 3 reference(s)