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Tg(Scgb1a1-rtTA,tetO-Il13)1Eli
Transgene Detail
Summary
Symbol: Tg(Scgb1a1-rtTA,tetO-Il13)1Eli
Name: transgene insertion 1, Jack A Elias
MGI ID: MGI:3835944
Synonyms: CC10-rtTA-IL-13, iIl-13
Transgene: Tg(Scgb1a1-rtTA,tetO-Il13)1Eli  Location: unknown  
Alliance: Tg(Scgb1a1-rtTA,tetO-Il13)1Eli page
Transgene
origin
Strain of Origin:  (CBA x C57BL/6)F2
Transgene
description
Transgene Type:    Transgenic (Inducible, Inserted expressed sequence, Transactivator)
Inducer:    doxycycline/tetracycline
Mutation:    Insertion
 
Tg(Scgb1a1-rtTA,tetO-Il13)1Eli expresses 1 gene
 
Mutation detailsThe CC10-rtTA-hGH construct contains the CC10 promoter, the reverse tetracycline transactivation (rtTA), and human growth hormone (hGH) intronic and polyadenylation sequences. The tet-O-CMV-IL-13-hGH construct contains a polymeric tetracycline operator (tet-O), minimal CMV promoter, murine IL-13 cDNA, and hGH intronic and polyadenylation signals. Both constructs were coinjected into fertilized oocytes, and dual positive founder animals were obtained. In the presence of doxycycline (dox), rtTA is able to bind in trans to the tet-O, and the VP-16 transactivator activates IL-13 gene transcription. In the absence of dox, rtTA binding occurs at very low levels, and only low level gene transcription is noted. (J:131678)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:131678 Zheng T, et al., Inducible targeting of IL-13 to the adult lung causes matrix metalloproteinase- and cathepsin-dependent emphysema. J Clin Invest. 2000 Nov;106(9):1081-93
All:  18 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory