Tg(MMTV-AURKA)#Cxd
Transgene Detail

Summary

• Symbol: Tg(MMTV-AURKA)#Cxd
• Name: transgene insertion, Chu-Xia Deng
• MGI ID: MGI:3836060
• Synonyms: MMTV-Aurora-A
• Transgene: Tg(MMTV-AURKA)#Cxd Location: unknown
• Alliance: Tg(MMTV-AURKA)#Cxd page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(MMTV-AURKA)#Cxd expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  AURKA (6790)

  Aurka

  (MGI:894678)

• Mutation details: The coding sequence for the human AURKA gene (Aurora-A) was placed under the control of the mouse mammary tumor virus enhancer and promoter. Six founder lines were established using the transgene construct with the two highest expressing lines pooled for phenotypic analysis. Transgene expression for both lines was highestin the mammary and salivary glands, followed by (in descending order of expression) kidney, spleen, liver, brain, and uterus. (J:145680)

Disease models

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:145680 Wang X, et al., Overexpression of aurora kinase A in mouse mammary epithelium induces genetic instability preceding mammary tumor formation. Oncogene. 2006 Nov 16;25(54):7148-58
• All: 1 reference(s)