Nfasc^tm1Bhat
Targeted Allele Detail

Summary

• Symbol: Nfasc^tm1Bhat
• Name: neurofascin; targeted mutation 1, Manzoor A Bhat
• MGI ID: MGI:3836177
• Synonyms: Nfasc^flox
• Gene: Nfasc Location: Chr1:132492428-132669535 bp, - strand Genetic Position: Chr1, 57.42 cM
• Alliance: Nfasc^tm1Bhat page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:145846
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An frt flanked neomycin selection cassette and a loxP site were inserted in intron 1. An additional loxP site was placed in intron 3. Excision of exons 2 and 3 will cause translation termination in exon 4. NF155 function will be ablated without affecting NF186. (J:145846)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nfasc Mutation: 61 strains or lines available

References

• Original: J:145846 Pillai AM, et al., Spatiotemporal ablation of myelinating glia-specific neurofascin (Nfasc NF155) in mice reveals gradual loss of paranodal axoglial junctions and concomitant disorganization of axonal domains. J Neurosci Res. 2009 Jun;87(8):1773-93
• All: 5 reference(s)