C2cd3^{Gt(AG0177)Wtsi}
Gene trapped Allele Detail

Summary

• Symbol: C2cd3^{Gt(AG0177)Wtsi}
• Name: C2 calcium-dependent domain containing 3; gene trap AG0177, Wellcome Trust Sanger Institute
• MGI ID: MGI:3836403
• Synonyms: C2cd3^GT
• Gene: C2cd3 Location: Chr7:100021440-100119359 bp, + strand Genetic Position: Chr7, 54.35 cM
• Alliance: C2cd3^{Gt(AG0177)Wtsi} page

Mutation origin

• Mutant Cell Line: AG0177
• Germline Transmission: Earliest citation of germline transmission: J:142506
• Parent Cell Line: E14TG2a.4 (ES Cell)
• Strain of Origin: 129P2/OlaHsd
• Project Collection: Sanger Inst. Gene Trap Res.

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector Vector: pGT0lxr
• Mutation details: A gene trap vector pGT0lxr containing lacZ was inserted into the third intron, disrupting C2cd3 transcription and splicing, resulting in a fusion protein between the N-terminal 161 residues of C2cd3 and beta-galactosidase. (J:142506)
• Inheritance: Recessive
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  AG0177	CL459267 ; (MGI Seq Detail)	5' RACE	Chr7:100029281-100029331 bp (+)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  9 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any C2cd3 Mutation: 101 strains or lines available

References

• Original: J:142506 Hoover AN, et al., C2cd3 is required for cilia formation and Hedgehog signaling in mouse. Development. 2008 Dec;135(24):4049-58
• All: 2 reference(s)