Aurka^tm1.1Tvd
Targeted Allele Detail

Summary

• Symbol: Aurka^tm1.1Tvd
• Name: aurora kinase A; targeted mutation 1.1, Terry Van Dyke
• MGI ID: MGI:3836420
• Synonyms: AurA^f, Aurka^fl
• Gene: Aurka Location: Chr2:172198110-172212455 bp, - strand Genetic Position: Chr2, 94.84 cM
• Alliance: Aurka^tm1.1Tvd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:145744
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An frt and loxP flanked neo cassette was inserted into intron 1 and a third loxP site was inserted into intron 2 via homologous recombination. Cre mediated recombination removed the neo cassette leaving exon 2 floxed. (J:145744)

Expression

In Mice Carrying this Mutation:	34 assay results
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Aurka Mutation: 40 strains or lines available

References

• Original: J:145744 Cowley DO, et al., Aurora-A kinase is essential for bipolar spindle formation and early development. Mol Cell Biol. 2009 Feb;29(4):1059-71
• All: 8 reference(s)