About   Help   FAQ
Ercc3tm1Jhjh
Targeted Allele Detail
Summary
Symbol: Ercc3tm1Jhjh
Name: excision repair cross-complementing rodent repair deficiency, complementation group 3; targeted mutation 1, Jan H J Hoeijmakers
MGI ID: MGI:3836421
Synonyms: Xpbfs
Gene: Ercc3  Location: Chr18:32373357-32403206 bp, + strand  Genetic Position: Chr18, 17.97 cM, cytoband B3
Alliance: Ercc3tm1Jhjh page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:145759
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted
Mutation:    Insertion
 
Mutation detailsFour bases (GATC) were inserted after the first codon in exon 15 and result in a frameshift that replaces the 41 C-terminal amino acids with 85 nonsense residues. Expression levels are 10-fold lower than in wild-type mice as confirmed by RT-PCR. (J:145759)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ercc3 Mutation:  32 strains or lines available
References
Original:  J:145759 Andressoo JO, et al., An Xpb mouse model for combined xeroderma pigmentosum and cockayne syndrome reveals progeroid features upon further attenuation of DNA repair. Mol Cell Biol. 2009 Mar;29(5):1276-90
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
10/22/2024
MGI 6.24
The Jackson Laboratory