Ercc3tm1Jhjh
Targeted Allele Detail
|
Symbol: |
Ercc3tm1Jhjh |
Name: |
excision repair cross-complementing rodent repair deficiency, complementation group 3; targeted mutation 1, Jan H J Hoeijmakers |
MGI ID: |
MGI:3836421 |
Synonyms: |
Xpbfs |
Gene: |
Ercc3 Location: Chr18:32373357-32403206 bp, + strand Genetic Position: Chr18, 17.97 cM, cytoband B3
|
Alliance: |
Ercc3tm1Jhjh page
|
|
Germline Transmission: |
Earliest citation of germline transmission:
J:145759
|
Parent Cell Line: |
Not Specified (ES Cell)
|
Strain of Origin: |
129P2/OlaHsd
|
|
Allele Type: |
|
Targeted |
Mutation: |
|
Insertion
|
|
|
Mutation details: Four bases (GATC) were inserted after the first codon in exon 15 and result in a frameshift that replaces the 41 C-terminal amino acids with 85 nonsense residues. Expression levels are 10-fold lower than in wild-type mice as confirmed by RT-PCR.
(J:145759)
|
|
|
View phenotypes and curated references for all genotypes (concatenated display).
|
Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
|
Carrying any Ercc3 Mutation: |
32 strains or lines available
|
|
Original: |
J:145759 Andressoo JO, et al., An Xpb mouse model for combined xeroderma pigmentosum and cockayne syndrome reveals progeroid features upon further attenuation of DNA repair. Mol Cell Biol. 2009 Mar;29(5):1276-90 |
All: |
1 reference(s) |
|