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Ercc3tm1Jhjh
Targeted Allele Detail
Summary
Symbol: Ercc3tm1Jhjh
Name: excision repair cross-complementing rodent repair deficiency, complementation group 3; targeted mutation 1, Jan H J Hoeijmakers
MGI ID: MGI:3836421
Synonyms: Xpbfs
Gene: Ercc3  Location: Chr18:32373357-32403206 bp, + strand  Genetic Position: Chr18, 17.97 cM, cytoband B3
Alliance: Ercc3tm1Jhjh page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:145759
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted
Mutation:    Insertion
 
Mutation detailsFour bases (GATC) were inserted after the first codon in exon 15 and result in a frameshift that replaces the 41 C-terminal amino acids with 85 nonsense residues. Expression levels are 10-fold lower than in wild-type mice as confirmed by RT-PCR. (J:145759)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ercc3 Mutation:  32 strains or lines available
References
Original:  J:145759 Andressoo JO, et al., An Xpb mouse model for combined xeroderma pigmentosum and cockayne syndrome reveals progeroid features upon further attenuation of DNA repair. Mol Cell Biol. 2009 Mar;29(5):1276-90
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory