Aurka^tm1.2Tvd
Targeted Allele Detail

Summary

• Symbol: Aurka^tm1.2Tvd
• Name: aurora kinase A; targeted mutation 1.2, Terry Van Dyke
• MGI ID: MGI:3836423
• Synonyms: AurA^d2
• Gene: Aurka Location: Chr2:172198110-172212455 bp, - strand Genetic Position: Chr2, 94.84 cM
• Alliance: Aurka^tm1.2Tvd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:145744
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An frt and loxP flanked neo cassette was inserted into intron 1 and a third loxP site was inserted into intron 2 via homologous recombination. Cre mediated recombination removed the neo cassette and exon 2. Deletion of exon 2 removes the ATg start site. Absence of protein expression was confirmed in blastocysts. (J:145744)

Expression

In Mice Carrying this Mutation:

18 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Aurka Mutation: 40 strains or lines available

References

• Original: J:145744 Cowley DO, et al., Aurora-A kinase is essential for bipolar spindle formation and early development. Mol Cell Biol. 2009 Feb;29(4):1059-71
• All: 1 reference(s)