Xrcc1^tm1Pmc
Targeted Allele Detail

Summary

• Symbol: Xrcc1^tm1Pmc
• Name: X-ray repair complementing defective repair in Chinese hamster cells 1; targeted mutation 1, Peter J McKinnon
• MGI ID: MGI:3836442
• Synonyms: Xrcc1^c, Xrcc1^Lox
• Gene: Xrcc1 Location: Chr7:24246124-24272863 bp, + strand Genetic Position: Chr7, 11.42 cM, cytoband A3-B2
• Alliance: Xrcc1^tm1Pmc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:145730
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A floxed neo cassette was inserted upstream of exon 4 and a loxP site was inserted downstream of exon 10. Transient cre mediated recombination in ES cells removed the neo cassette leaving exons 4 through 10 floxed. (J:152528)

Expression

In Mice Carrying this Mutation:	2 assay results
In Structures Affected by this Mutation:	9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Xrcc1 Mutation: 45 strains or lines available

References

• Original: J:145730 Reynolds JJ, et al., Defective DNA ligation during short-patch single-strand break repair in ataxia oculomotor apraxia 1. Mol Cell Biol. 2009 Mar;29(5):1354-62
• All: 14 reference(s)