Tg(Chat-cre)GM24Gsat
Transgene Detail

Summary

• Symbol: Tg(Chat-cre)GM24Gsat
• Name: transgene insertion GM24, GENSAT Project at Rockefeller University
• MGI ID: MGI:3836624
• Synonyms: GM24, Tg(Chat-cre)24Gsat
• Transgene: Tg(Chat-cre)GM24Gsat Location: unknown
• Alliance: Tg(Chat-cre)GM24Gsat page

Transgene origin

• Strain of Origin: FVB/N
• Project Collection: GENSAT

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Chat-cre)GM24Gsat expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Chat (MGI:88392)

• Mutation details: A Cre-expression cassette, followed by a polyadenylation sequence to terminate transcription of the fusion transcript immediately after the recombinase gene, was inserted into a BAC vector at the initiating ATG codon in the first coding exon of the gene. The Cre expression pattern matches adult Chat gene expression (all cholinergic neurons) and is limited to motor neurons, with minimal expression in forebrain structures. (J:145110)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Chat (mouse) Summary of all recombinase alleles driven by Chat. Comparative matrix view of recombinase activities Alliance mouse Chat gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available

References

• Original: J:145110 Gong S, et al., Targeting Cre recombinase to specific neuron populations with bacterial artificial chromosome constructs. J Neurosci. 2007 Sep 12;27(37):9817-23
• All: 37 reference(s)