Slamf7^tm1Vei
Targeted Allele Detail

Summary

• Symbol: Slamf7^tm1Vei
• Name: SLAM family member 7; targeted mutation 1, Andre Veillette
• MGI ID: MGI:3836722
• Synonyms: CRACC^-
• Gene: Slamf7 Location: Chr1:171459971-171480603 bp, - strand Genetic Position: Chr1, 79.54 cM, cytoband H2
• Alliance: Slamf7^tm1Vei page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:145969
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A Frt-flanked neomycin resistance cassette and a stop codon were inserted into exon 1. The neomycin cassette was removed by transient expression of Flpe recombinase. Gene inactivation was confirmed by flow cytometry and immunoblot analysis of splenic natural killer (NK) cells from homozygote mice. Expression of other SLAM family members were unaffected on NK cells. (J:145969)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slamf7 Mutation: 20 strains or lines available

References

• Original: J:145969 Cruz-Munoz ME, et al., Influence of CRACC, a SLAM family receptor coupled to the adaptor EAT-2, on natural killer cell function. Nat Immunol. 2009 Mar;10(3):297-305
• All: 3 reference(s)