Sh2d1b1^tm2Vei
Targeted Allele Detail

Summary

• Symbol: Sh2d1b1^tm2Vei
• Name: SH2 domain containing 1B1; targeted mutation 2, Andre Veillette
• MGI ID: MGI:3836736
• Synonyms: EAT-2^-
• Gene: Sh2d1b1 Location: Chr1:170104889-170114338 bp, + strand Genetic Position: Chr1, 76.84 cM, cytoband H2
• Alliance: Sh2d1b1^tm2Vei page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:145969
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: ES cells carrying the Sh2d1b2^tm1Vei (ERT) null allele were targeted again with a hygromycin cassette to the Sh2d1b1 locus to create a second null allele. The two null alleles were in cis with each other, and were located 26 kb apart. (J:145969)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sh2d1b1 Mutation: 11 strains or lines available

References

• Original: J:145969 Cruz-Munoz ME, et al., Influence of CRACC, a SLAM family receptor coupled to the adaptor EAT-2, on natural killer cell function. Nat Immunol. 2009 Mar;10(3):297-305
• All: 3 reference(s)