Cyp2j5^tm1Dcz
Targeted Allele Detail

Summary

• Symbol: Cyp2j5^tm1Dcz
• Name: cytochrome P450, family 2, subfamily j, polypeptide 5; targeted mutation 1, Darryl C Zeldin
• MGI ID: MGI:3836754
• Gene: Cyp2j5 Location: Chr4:96517010-96552391 bp, - strand Genetic Position: Chr4, 44.71 cM
• Alliance: Cyp2j5^tm1Dcz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:146047
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 9 was replaced with a neo cassette via homologous recombination. RT-PCR and immunoblotting analysis confirmed the absence of expression in kidneys from homozygous mice. (J:146047)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cyp2j5 Mutation: 29 strains or lines available

References

• Original: J:146047 Athirakul K, et al., Increased blood pressure in mice lacking cytochrome P450 2J5. FASEB J. 2008 Dec;22(12):4096-108
• All: 3 reference(s)