Kcnk10^tm1Fles
Targeted Allele Detail

Summary

• Symbol: Kcnk10^tm1Fles
• Name: potassium channel, subfamily K, member 10; targeted mutation 1, Florian Lesage
• MGI ID: MGI:3836779
• Synonyms: TREK2^-
• Gene: Kcnk10 Location: Chr12:98395691-98544472 bp, - strand Genetic Position: Chr12, 49.86 cM, cytoband F1
• Alliance: Kcnk10^tm1Fles page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:145944
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Gene gap repair was used to duplicate exon 2 and inserted a neo cassette between the two copies of exon 2. The absence of protein expression was confirmed by western blot analysis on brain extracts. (J:145944)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kcnk10 Mutation: 32 strains or lines available

References

• Original: J:145944 Guyon A, et al., Glucose inhibition persists in hypothalamic neurons lacking tandem-pore K+ channels. J Neurosci. 2009 Feb 25;29(8):2528-33
• All: 8 reference(s)