Thrb^tm1Mkni
Targeted Allele Detail

Summary

• Symbol: Thrb^tm1Mkni
• Name: thyroid hormone receptor beta; targeted mutation 1, Marlies Knipper
• MGI ID: MGI:3836780
• Synonyms: Thrb^tm1.1Sasr, TRbeta^flox, TRbeta L2, TRbeta^lox
• Gene: Thrb Location: Chr14:4431611-4809435 bp, - strand Genetic Position: Chr14, 7.08 cM, cytoband A3
• Alliance: Thrb^tm1Mkni page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:145941
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: LoxP sites were introduced 5' and 3' of exon 8 and an FRT site flanked neomycin resistance gene cassette was introduced downstream of the 3' loxP site in intron 8. The neo cassette was then removed by Flp-mediated recombination leaving behind a single FRT site. (J:145941)

Expression

In Mice Carrying this Mutation:	44 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Thrb Mutation: 41 strains or lines available

References

• Original: J:145941 Winter H, et al., Deafness in TRbeta mutants is caused by malformation of the tectorial membrane. J Neurosci. 2009 Feb 25;29(8):2581-7
• All: 13 reference(s)