Lrrtm1^tm1Amcr
Targeted Allele Detail

Summary

• Symbol: Lrrtm1^tm1Amcr
• Name: leucine rich repeat transmembrane neuronal 1; targeted mutation 1, Ann Marie Craig
• MGI ID: MGI:3836788
• Gene: Lrrtm1 Location: Chr6:77219672-77234774 bp, + strand Genetic Position: Chr6, 33.89 cM
• Alliance: Lrrtm1^tm1Amcr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:145907
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2 which encodes the entire open reading frame was replaced with an IRES-tauLacZ followed by a floxed neo cassette via homologous recombination. The neo cassette was later removed leaving behind a single loxP site. (J:145907)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lrrtm1 Mutation: 37 strains or lines available

References

• Original: J:145907 Linhoff MW, et al., An unbiased expression screen for synaptogenic proteins identifies the LRRTM protein family as synaptic organizers. Neuron. 2009 Mar 12;61(5):734-49
• All: 3 reference(s)