Map3k3^tm2Bisu
Targeted Allele Detail

Summary

• Symbol: Map3k3^tm2Bisu
• Name: mitogen-activated protein kinase kinase kinase 3; targeted mutation 2, Bing Su
• MGI ID: MGI:3836798
• Synonyms: MEKK3^fl
• Gene: Map3k3 Location: Chr11:105975439-106046272 bp, + strand Genetic Position: Chr11, 68.89 cM
• Alliance: Map3k3^tm2Bisu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:145923
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted into the XbaI site upstream of exon 15, and a loxP site and a FRT-flanked neomycin resistance cassette were inserted downstream of exon 15 at another XbaI site. The neomycin cassette was removed by crossing with FLPe recombinase transgenic mice. The floxed exon encodes the kinase subdomains VII and VIII of the protein product. (J:145923)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Map3k3 Mutation: 27 strains or lines available

References

• Original: J:145923 Wang X, et al., MEKK3 is essential for lymphopenia-induced T cell proliferation and survival. J Immunol. 2009 Mar 15;182(6):3597-608
• All: 6 reference(s)