Tg(ACTB-Twnk*)DSuom
Transgene Detail

Summary

• Symbol: Tg(ACTB-Twnk*)DSuom
• Name: transgene insertion D, Anu Suomalainen
• MGI ID: MGI:3836897
• Synonyms: Tg(ACTB-Peo1*)DSuom, Twinkle^dup
• Transgene: Tg(ACTB-Twnk*)DSuom Location: unknown
• Alliance: Tg(ACTB-Twnk*)DSuom page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(ACTB-Twnk*)DSuom expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Twnk (MGI:2137410)

• Mutation details: The human promoter was used to drive ubiquitous expression of the mouse gene with a silent point mutation at position 1077 (c.1077C->G) that forms a restriction enzyme site and allows for the insertion of 39 nucleotides. This produces a duplication of amino acids 353 to 365. Four lines were produced (C, D, E, and F) with line D selected as the representative line. (J:104378)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:104378 Tyynismaa H, et al., Mutant mitochondrial helicase Twinkle causes multiple mtDNA deletions and a late-onset mitochondrial disease in mice. Proc Natl Acad Sci U S A. 2005 Dec 6;102(49):17687-92
• All: 6 reference(s)