Tg(ACTB-Twnk*A360T)HSuom
Transgene Detail

Summary

• Symbol: Tg(ACTB-Twnk*A360T)HSuom
• Name: transgene insertion H, Anu Suomalainen
• MGI ID: MGI:3836898
• Synonyms: Tg(ACTB-Peo1*A360T)HSuom, Twinkle^AT
• Transgene: Tg(ACTB-Twnk*A360T)HSuom Location: unknown
• Alliance: Tg(ACTB-Twnk*A360T)HSuom page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(ACTB-Twnk*A360T)HSuom expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Twnk (MGI:2137410)	Transgene codes for a protein with an alanine to threonine mutation.

• Mutation details: The human promoter was used to drive ubiquitous expression of the mouse gene with a point mutation that results in the amino acid substitution of threonine for alanine at position 360. Three lines were produced (G, H, and I) with line H selected as the representative line. (J:104378)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:104378 Tyynismaa H, et al., Mutant mitochondrial helicase Twinkle causes multiple mtDNA deletions and a late-onset mitochondrial disease in mice. Proc Natl Acad Sci U S A. 2005 Dec 6;102(49):17687-92
• All: 3 reference(s)