Trip11^{Gt(AJ0490)Wtsi}
Gene trapped Allele Detail

Summary

• Symbol: Trip11^{Gt(AJ0490)Wtsi}
• Name: thyroid hormone receptor interactor 11; gene trap AJ0490, Wellcome Trust Sanger Institute
• MGI ID: MGI:3836913
• Synonyms: GMAP210^-
• Gene: Trip11 Location: Chr12:101800304-101879463 bp, - strand Genetic Position: Chr12, 51.3 cM, cytoband F1
• Alliance: Trip11^{Gt(AJ0490)Wtsi} page

Omphalocele and cardiovascular and lung defects in Trip11^{Gt(AJ0490)Wtsi}/Trip11^{Gt(AJ0490)Wtsi} mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Mutant Cell Line: AJ0490
• Germline Transmission: Earliest citation of germline transmission: J:142875
• Parent Cell Line: E14TG2a.4 (ES Cell)
• Strain of Origin: 129P2/OlaHsd
• Project Collection: Sanger Inst. Gene Trap Res.

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector Vector: pGT0lxr
• Mutation details: The gene trap vector, which contains a beta-geo cassette, was inserted into intron 4. This allele also contains a 531 bp insertion derived by duplication from chromosome 16 at the junction between the vector and intron 4. The absence of protein expression was confirmed by western blot analysis on mouse embryonic fibroblast extracts. (J:142875)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  AJ0490	CL525062 ; (MGI Seq Detail)	5' RACE	Chr12:101865083-101868582 bp (-)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  9 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trip11 Mutation: 99 strains or lines available

References

• Original: J:142875 Follit JA, et al., The Golgin GMAP210/TRIP11 anchors IFT20 to the Golgi complex. PLoS Genet. 2008 Dec;4(12):e1000315
• All: 4 reference(s)