Ednra^tm2Hku
Targeted Allele Detail

Summary

• Symbol: Ednra^tm2Hku
• Name: endothelin receptor type A; targeted mutation 2, Hiroki Kurihara
• MGI ID: MGI:3836966
• Synonyms: Ednra^lacZ2FRT
• Gene: Ednra Location: Chr8:78389658-78451081 bp, - strand Genetic Position: Chr8, 36.63 cM, cytoband C2
• Alliance: Ednra^tm2Hku page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:131382
• Parent Cell Line: ATOM1 (ES Cell)
• Strain of Origin: (C57BL/6 x 129)F1

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: Using RMCE with transient cre recombinase expression, the neo cassette of Ednra^tm1Hku was replaced with a floxed cassette containing a lacZ gene and an frt-flanked puromycin resistance cassette. Expression of the lacZ gene was confirmed by beta-galactosidase assay. (J:131382)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ednra Mutation: 35 strains or lines available

References

• Original: J:131382 Sato T, et al., Recombinase-mediated cassette exchange reveals the selective use of Gq/G11-dependent and -independent endothelin 1/endothelin type A receptor signaling in pharyngeal arch development. Development. 2008 Feb;135(4):755-65
• All: 1 reference(s)